Anticancer Gold Compounds

Despite advances in new modalities of cancer therapy, chemotherapy may be unavoidably used for those advanced cancer patients who fail to respond to targeted therapy and immunotherapy. Au1 show proven anticancer activities and hold promise as targeted chemotherapeutics.

• Au1 exhibit effective anticancer activities in patient derived tumour organoids and mice models of diversified human cancer types including liver, colon, nasopharyneal, ovarian and lung carcinoma
• Au1 suppress orthrotopic hepatocellular carcinoma growth and impede metastatic spread to lung in mice.
• PEGylated Au1 having improved safety pharmacology profile show significant inhibition in the tumour growth in mice bearing EBV+ve nasopharyneal carcinoma xenograft.
• Antibody-drug conjugate of Au1 for improving tumor delivery has been developed.

• Au1 target anticancer molecular targets (e.g. heat shock protein, aminopeptidase, thioredoxin) that lack therapeutic inhibitors.
• Au1 exhibit effective anti-tumor activities and impede metastasis in advanced stage cancer models.
• Au1 are desirable payloads of drug-targeting conjugates and lipid nanoparticle formulations which show marked shrinking effects on targeted tumours in mice.

• Investigational New Drug application in preparartion

• US11,135,310
• ZL201680081386.0
• EP3386986