Integrated Digital-PCR-on-a-disc Device

Overview

The project develops an integrated digital PCR disc laboratory (D-DISC) platform for rapid on-site diagnosis of infectious diseases in cross-border field, which will lead to "sample-to-answer"operation by measuring absolute quantity of genetic molecular products amplified through digital polymerase chain reaction (digital-PCR).

  • Integrated Digital-PCR-on-a-disc Device 0
  • Integrated Digital-PCR-on-a-disc Device 1
  • Integrated Digital-PCR-on-a-disc Device 2
Technical name of innovation
A High Throughput Digital-PCR-on-a-disc System for Rapid On-site Cross-border Inspection of Infectious Diseases
Research completion
2022
Commercialisation opportunities
technology licensing agreement
Problem addressed

Cross-border inspection is an important issue in Shenzhen-Hong Kong region, but currently there is a lack of any rapid on-site inspection facility that can be operated conveniently by cross-boarder staff. To solve this problem, this project developed a small integrated prototype for rapid on-site screening of infectious diseases in cross-border.

Innovation
  • A fully integrated, portable, all-in-one lab-on-disc prototype for absolute quantification nucleic acid detection.
  • A high-throughput, pumpless, stable droplet generation system based on centrifugal force.
  • It can be used for the absolute quantitative detection of a variety of pathogens.
Key impact
  • It leads to "sample-to-answer" operation by measuring absolute quantity of genetic molecular products amplified through digital polymerase chain reaction (digital-PCR).
  • It has great stability in high-thought centrifugal force-based droplet generation.
  • It was able to implement different infectious diseases, and 20 kinds of virus samples were tested with the prototype, which also shows great potential for commercialization.
Award
  • Champion in Postgraduate Individual of Professor Charles K. Kao Student Creativity Awards 2021
  • Special Award of Professor Charles K. Kao Student Creativity Awards 2021（Life Sciences）
  • The Bronze Award at the Workshop of the Optoelectronics Global Conference held in Shenzhen, China Sep 2020
  • Key Technology Research of Surface plasmon Phase spectroscopy and its application in rapid diagnosis of infectious diseases, Shenzhen Science and Technology Progress Award 2019 (Social Welfare Category)
  • Champion in Postgraduate Individual of Professor Charles K. Kao Student Creativity Awards 2019 May 2019
  • Special Award of Professor Charles K. Kao Student Creativity Awards 2019 May 2019
  • Merit Award of the 5th Hong Kong University Student Innovation and Entrepreneurship Competition May 2019
Application
  • On-site infectious disease detection in cross-border

Patent

  • Patent:202110436550.8
  • Patent:ZL 202110493052.7
  • Patent:2020100366
  • Patent:CN201610664314.0
The Chinese University of Hong Kong (CUHK)

Founded in 1963, The Chinese University of Hong Kong (CUHK) is a forward-looking comprehensive research university with a global vision and a mission to combine tradition with modernity, and to bring together China and the West. CUHK teachers and students hail from all around the world. Four Nobel laureates are associated with the university, and it is the only tertiary institution in Hong Kong with recipients of the Nobel Prize, Turing Award, Fields Medal and Veblen Prize sitting as faculty in residence. CUHK graduates are connected worldwide through an extensive alumni network. CUHK undertakes a wide range of research programmes in many subject areas, and strives to provide scope for all academic staff to undertake consultancy and collaborative projects with industry. 

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