Photoenhanced cytosolic protein delivery platform
Overview
This invention is about a photosensitive drug delivery system for enhancing cytosolic protein delivery.
Commercialisation opportunities
collaboration project, licensing
Problem addressed
Over the past decades, there has been emerging interest in using active proteins for various biological applications, such as cancer therapy, gene editing, and vaccination. However, development on cytosolic protein delivery focusing on intracellular targets is still challenging, mainly due to their large molecular weights, low cellular affinity, and poor endosomal escape ability.
Innovation
- The nanocarrier can protect the cargo protein during blood circulation.
- The photoresponsive moiety inside the nanocarrier can offer an on-demond drug delivery.
Key impact
- Significantly enhanced intracellular protein delivery paves the way for the application of therapeutic proteins functioning intracellularly
- Phototriggered drug release offers a targeting treatment
- Simple preparation process results in low cost
Application
- Intracellular delivery of therapeutic proteins
- Gene editing
Patent
- PCT/CN2022/097804
The University of Hong Kong (HKU)
Founded in 1911, The University of Hong Kong (HKU) is the first and oldest institution of higher education in Hong Kong. For over a century, the University has dedicated itself to creating knowledge, providing education, and serving society. Today, HKU has an established worldwide reputation for being a research-led comprehensive University with ten Faculties and a strong commitment to intellectual freedom, liberty and diversity. HKU has a proud record of academic recognition in researches through honours and awards received from both local and international bodies.
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