Pharmaceutical composition with anti-colorectal cancer effect and application thereof

Colorectal cancer is a prevalent malignant tumor that poses a significant threat to human health. Current treatment options include surgery, chemotherapy, targeted therapy, and immunotherapy. However, the survival rate for metastatic colorectal cancer remains low. Therefore, there is an urgent need for new, cost-effective, and efficient anti-colorectal cancer drugs.

• The present invention relates to a pharmaceutical composition comprising: (1) Isorhamnetin or a derivative thereof, and (2) an autophagy inhibitor.
• Invention also relates to the use of a combination of isorhamnetin or a derivative thereof and an autophagy inhibiting agent for the preparation of a medicament for the treatment of a proliferative disease.

• The isorhamnetin and the autophagy inhibitor in the pharmaceutical composition have obvious synergistic effect and good colorectal cancer resistance effect.

• Pharmaceutical composition with anti-colorectal cancer effect and application

• China Patent Publication No.: CN115887664A