A Microfluidic Biosensing System for Improved Cancer Diagnostics and Screening

A portable biosensing system for early cancer diagnostics and screening. It provides fast measurement with significantly improved sensitivity, convenient cancer screening, lower cost, and higher level of accuracy.

• A portable microfluidic biosensing system for detection of cancer at low concentration, with biosensor capable of trapping small size cancer markers and sensing small changes.
• Nanometer-size cancer markers could be detected by the biosensor, while electrical force could be applied to increase trapping efficiency of cancer markers in order to increases detection sensitivity.
• Fabrication technology, materials, and system design for the biosensing system to provide sensitive, low noise optical detection based on resonant peak shift.

• Low manufacturing and operating cost compared to existing apparatus that performs similar function.
• More convenient to use, which is portable, small size, and with simpler setup.
• Faster than existing apparatus, shorter time required to produce a result.
• Low sample volume, which reduced sample volume from tens of ml to µl, while having high sensitivity to detect cancer at low concentration.

• Bronze Medal at Inventions Geneva Evaluation Days 2021

• Early stage cancer detection and diagnostic.
• Convenience of use by medical practitioners as a portable system that can be used on daily applications that require point-of-care and low-cost setup.
• Extendable to other disease screening as exosomes are shown to play essential role in health and disease indication.
• Applicable to trapping and detection of various biomolecules for early disease diagnostic as this biosensor can monitor micrometer to nanometer size particles at low concentration.

• United States Patent Application No. 16/532,636