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Artificial Intelligence-guided and Personalised Fecal Microbiota Transplantation (FMT) Treatment for Human Diseases

Overview

Recent evidence suggests that imbalance in the gut microbiota can lead to many human diseases. Although microbiota-based therapeutics appears promising, the science behind this is still in its infancy.

  • Artificial Intelligence-guided and Personalised Fecal Microbiota Transplantation (FMT) Treatment for Human Diseases 0
  • Artificial Intelligence-guided and Personalised Fecal Microbiota Transplantation (FMT) Treatment for Human Diseases 1
  • Artificial Intelligence-guided and Personalised Fecal Microbiota Transplantation (FMT) Treatment for Human Diseases 2
Commercialisation opportunities
Exclusive licensing
Problem addressed

Many Diseases are Related to Imbalance of Gut Microbiota (Dysbiosis), including Obesity, Irritable Bowel Syndrome, Inflammatory Bowel Disease, C. Difficile Colitis (CDI), and Graft-Versus-Host Disease. 

Innovation
  • With Fecal Microbiota Transplantation (FMT), we can restore the bablance of gut microbiota
  • Using Fecal Microbiota Transplantation (FMT) to treat patients with severe Clostridium difficile (C. difficile) infection.
Key impact
  • The cure rate of treating patients with severe Clostridium difficile (C. difficile) infection is over 85% when using FMT, which is significantly higher than that of conventional antibiotic treatment.
Award
  • Geneva International Exhibition of Inventions - Silver Medal
Application
  • Apply FMT in other digestive diseases such as irritable bowel syndrome and ulcerative colitis

Patent

  • Fecal Fungome and Therapeutic Efficacy of Fecal Microbiota Transplantation - Patent Application: TW (108104139), US (16/966,853), UK (2012957.3), HK (62021034325.2)
  • Fecal Virome and Therapeutic Efficacy of Fecal Microbiota Transplantation – Patent Application: US (16/292907)
  • Therapeutic and Prophylactic Use of Microorganisms - Patent Application: TW (108148047), US (17/417,732 ), CN (201980088391.8)
  • Methods for Treating Bacterial Infections - Patent Application: US (62/946,781), TW (109143818), PCT (PCT/CN2020/135614)
The Chinese University of Hong Kong (CUHK)

Founded in 1963, The Chinese University of Hong Kong (CUHK) is a forward-looking comprehensive research university with a global vision and a mission to combine tradition with modernity, and to bring together China and the West. CUHK teachers and students hail from all around the world. Four Nobel laureates are associated with the university, and it is the only tertiary institution in Hong Kong with recipients of the Nobel Prize, Turing Award, Fields Medal and Veblen Prize sitting as faculty in residence. CUHK graduates are connected worldwide through an extensive alumni network. CUHK undertakes a wide range of research programmes in many subject areas, and strives to provide scope for all academic staff to undertake consultancy and collaborative projects with industry. 

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