Nano-vesicles for Improving Drug’s Stability and Efficacy to Treat Chronic Diseases

The diabetes and asthma drugs will be quickly metabolized by the human body and the therapeutic effect of active pharmaceutical ingredients can only last for a short period.

• We have developed a new protective layer manufacturing technology with high encapsulation efficiency. Solid lipid vesicles are manufactured to encapsulate the drugs and serve as a drug delivery system.
• This not only achieves a better drug delivery effect but also increases the effective time and stability of the drug. Our animal study demonstrated a slow transportation rate of pharmaceutical ingredients encapsulated in liposomes and showed that the rapid loss of drugs in the body is prevented.

• With this technolgoy, the frequency of drug administration, dosage, side effects of the drugs can be reduced.
• Taking Salbutamol sulfate (SBS), a model asthma alleviating drug as an example, if this technology is applied, the therapeutic effect of SBS can be prolonged by 4 times, and patients only need to take the drug once a day. This will greatly reduce the inconvenience in patients' daily lives.

• The technology can be used to fabricate dehydrated lipid vesicles for drug delivery, such as: - encapsulating existing drugs for common chronic diseases like diabetes and asthma
• fabricating aerosolized liposome carrier for pulmonary delivery of SBS
• conjugating with targeting ligands to enrich site-specific therapeutic action

• China Patent No. ZL 2014 1 0055853.5
• Hong Kong Patent No. HK 1208626
• Japan Patent No. JP 6305555
• US Patent No. US 9,980,906