Theranostic AIEgens for Diagnosis and Treatment of Cancer & Alzheimer's Disease
Overview
Aggregation-induced emission (AIE) luminogens (AIEgens) creates new expectations and opportunities in the biomedical field due to their outstanding fluorescent property. The mitochondrial probe can be co stained with blue, green, yellow and red probes for a whole spectrum fluorescence.
Commercialisation opportunities
Technology licensing agreement
Problem addressed
Avoid serious self-quenching after being at high concentration, which minimizes the diagnosis and treatment effect
Innovation
- AIEgens are ideal for construction of cancer & Alzheimer's Disease theranostics with advantages of high emission efficiency in aggregate state
- A great opportunity for image-guided precise cancer and Alzheimer's disease treatment
Key impact
- Free of aggregation-caused quenching (ACQ) at high concentration
- Excellent photostability, large Stokes shift, high signal-to-noise ratio
- High brightness, strong anti-photobleaching ability
- Kill cancer cells/A-beta when integrated with photodynamic effect
Application
- Diagnostic agent for cancer and Alzheimer's Disease
- Photodynamic agent for treatment of cancer and Alzheimer's Disease
- Clinical research reagent for cancer and Alzheimer's Disease imaging
Patent
- US Patent 16/614141 63/274945 17/248340 63/167624
- CNIPA Chinese Patent Application 202110080829.7 202010598550.3 201880089767.2 201880021153.0
- HK Patent Application 42021029166.2
The Hong Kong University of Science and Technology (HKUST)
The Hong Kong University of Science and Technology (HKUST) (https://hkust.edu.hk/) is a world-class research intensive university that focuses on science, technology and business as well as humanities and social science. HKUST offers an international campus, and a holistic and interdisciplinary pedagogy to nurture well-rounded graduates with global vision, a strong entrepreneurial spirit and innovative thinking. Over 80% of our research work were rated “Internationally excellent” or “world leading” in the Research Assessment Exercise 2020 of Hong Kong’s University Grants Committee. We were ranked 3rd in Times Higher Education’s Young University Rankings 2022, and our graduates were ranked 23rd worldwide and among the best from universities from Asia in Global University Employability Survey 2021.
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